Persönlicher Status und Werkzeuge

Sprachwahl

 

Philipp Heckmeier

PhD student

 

Lehrstuhl für Chemie der Biopolymere
Weihenstephaner Berg 3

85354 Freising
Tel.: +49(0)8161 71 3503
Fax: +49(0)8161 71 4404

 

Room number: E/1.02

philipp.heckmeier[at]tum.de

 

    Since 01/2015: PhD student at the Langosch lab, Technische Universität München

  • 2011 – 2014: Master studies in Molecular Biotechnology, Technische Universität München
    Master’s Thesis: Establishment of an inducible heterologous expression system in HEK293 for the functional characterization of the uncoupling protein 1 (UCP1), 2014; Chair of Molecular Nutritional Medicine (Prof. Dr. Martin Klingenspor), Technische Universität München
  • 2012 – 2013: Studies in Molecular Biotechnology at the University of Málaga, Spain
  • 2008 – 2011: Bachelor studies in Molecular Biotechnology, Technische Universität München
    Bachelor’s Thesis: Purification of a therapeutical protein by crystallization; Chair of Biochemical Engineering (Prof. Dr.-Ing. Dirk Weuster-Botz), Technische Universität München

 

Research:

Transmembrane proteins are essential for cell communication, cellular growth and many other cellular processes. From a medical view, they are also of special interest, reflected in the high number of pharmaceutical compounds that target membrane proteins.

Protein-protein interaction at the cell surface is vital for the function of many transmembrane proteins. Understanding these interactions could unveil new aspects which are relevant for pharmaceutical applications.

There are several genetic reporter assays to measure transmembrane protein interaction like the ToxR assay. These techniques allow the characterization of homotypic or heterotypic interactions, particularly for dimerizing membrane proteins. Though, the characterization of interactions with a higher oligomerization state still remains difficult. In my project, I use a new method to distinguish between different stoichiometries (dimer, trimer, tetramer, pentamer, etc.) of proteins that interact via their transmembrane domain.

 

Methods:

Genetic engineering of E. coli; membrane protein expression, purification and reconstitution; fluorescence measurements; bioinformatic analysis of data generated with reporter assays

 

Research Internships available (Bachelor/Master):

If you are interested to join our group for your thesis or an internship (minimum: 8 weeks), write me an email with a few sentences about yourself, your motivation and include your latest transcript of records (Notenliste).

Personal Interests:

Apart from science, I am interested in art, languages and politics. I love to play piano and golf.