Persönlicher Status und Werkzeuge

Sprachwahl

 

Dr. Mark Teese

Postdoc

 

Lehrstuhl für Chemie der Biopolymere
Weihenstephaner Berg 3
85354 Freising
Tel.: +49(0)8161 71 3503
Fax: +49(0)8161 71 4404

 

Room number: E/1.02

mark.teese[at]tum.de

 

  • 1995 - 1997 High School, St Peter's Lutheran College, Brisbane, Australia
  • 1998 - 2002 Studies in Biotechnology, University of Queensland, Australia. Honours research year in molecular microbiology in the lab of Prof. Linda Blackall.
  • 2002 Bachelor of Biotechnology granted (Honours Class IIA), University of Queensland, Australia
  • 2003, 2004 Researcher, Leibniz Institut für Polymerforschung, Dresden, Germany
  • 2005 - 2011 PhD studies, Russell/Oakeshott Lab, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
  • 2010 Postdoctoral fellow, Jose Lab, Institute of pharmaceutical and medicinal chemistry, University of Düsseldorf
  • 2011 -2012 Postdoctoral fellow, Jose Lab, Institute of pharmaceutical and medicinal chemistry, University of Münster
  • Since 05/2013 –Postdoctoral fellow, Langosch lab, Technische Universität München

 

 

Research:

Membrane proteins mediate many cellular processes including signal transduction and cell-cell interactions. These processes are involved in the development of many diseases. However the study of membrane proteins remains challenging and therefore many aspects of their biogenesis and function remain poorly understood. One of these aspects is the interaction between transmembrane domains (TMDs) of proteins located in cellular membranes. Specific sequence motifs such as GxxxG have been associated with dimerisation. However the presence of these motifs alone is not sufficient to predict dimerisation. The number of membrane proteins that rely on TMD dimerisation for their correct function is currently unknown. The dynamics of TMD dimerisation appears to be a complex process mediated by both electrostatic and Van der Waals forces and is affected by the TMD sequence and the composition of the surrounding membrane. My research aim is to understand the specific interaction of transmembrane domains using a variety of techniques including bioinformatics, molecular biology and protein biochemistry.

 

 

Theses:

PhD Thesis:

The carboxyl/cholinesterases of Helicoverpa armigera: A comparative genomic, proteomic and expression analysis of a diverse gene superfamily. (2010); Australian National University

Honours Thesis:

Polyphosphate accumulating organisms in wastewater treatment. (2002); University of Queensland, Australia.

Honours Business Plan:

The production of the biopesticide Bacillus thuringiensis kurstaki from wastewater solids (2002); University of Queensland, Australia.

 

Publications:

Teese MG & Langosch D (2015) The role of GxxxG motifs in transmembrane domain interactions. Biochemistry (accepted manuscript):  http://dx.doi.org/10.1021/acs.biochem.5b00495.

Sichwart S, Tozakidis IEP, Teese M & Jose J (2015) Maximized Autotransporter Mediated Expression (MATE) for surface display and secretion of recombinant proteins in Escherichia coli. Food Technology and Biotechnology (accepted manuscript): 10.17113/ftb.53.03.15.3802

Jose J, Teese MG, Sichwart S & Tozakidis I. (2014). World Patent No. WO2014139862 (A1). Improved surface display of functional proteins in a broad range of gram negative bacteria.  Application date 2014-03-06, Publication date 2014-09-18.

Tozakidis IEP, Sichwart S, Teese MG & Jose J (2014) Autotransporter mediated esterase display on Zymomonas mobilis and Zymobacter palmae. Journal of Biotechnology 191: 228-235. http://dx.doi.org/10.1016/j.jbiotec.2014.07.009.

Tubeleviciute A, Teese MG & Jose J (2014) Escherichia coli kduD encodes an oxidoreductase that converts both sugar and steroid substrates. Applied Microbiology and Biotechnology 98 (12): 5471-5485 http://dx.doi.org/10.1007/s00253-014-5551-8.

Teese MG, Farnsworth CA, Li Y, Coppin CW, Devonshire AL, Scott C, East P, Russell RJ & Oakeshott JG (2013) Heterologous expression and biochemical characterisation of fourteen esterases from Helicoverpa armigera. PLoS ONE 8: (6)e65951 http://dx.doi.org/10.1371/journal.pone.0065951.

Li Y, Farnsworth CA, Coppin CW, Teese MG, Liu J-W, Scott C, Zhang X, Russell RJ & Oakeshott JG (2013) Organophosphate and pyrethroid hydrolase activities of mutant esterases from the cotton bollworm Helicoverpa armigera. PLoS ONE 8: (10)e77685 http://dx.doi.org/10.1371/journal.pone.0077685.

Löppenberg M, Muller H, Pulina C, Oddo A, Teese M, Jose J & Holl R (2013) Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors. Organic & Biomolecular Chemistry 11: (36)6056-6070 http://dx.doi.org/10.1039/C3OB41082J.

Jose J, Maas RM & Teese MG (2012) Autodisplay of enzymes—Molecular basis and perspectives. Journal of Biotechnology 161: (2)92-103 http://dx.doi.org/10.1016/j.jbiotec.2012.04.001.

Schumacher SD, Hannemann F, Teese MG, Bernhardt R & Jose J (2012) Autodisplay of functional CYP106A2 in Escherichia coli. Journal of Biotechnology 161: (2)104-112 http://dx.doi.org/10.1016/j.jbiotec.2012.02.018.

Wu S, Yang Y, Yuan G, Campbell PM, Teese MG, Russell RJ, Oakeshott JG & Wu Y (2011) Overexpressed esterases in a fenvalerate resistant strain of the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology 41: (1)14-21 http://dx.doi.org/10.1016/j.ibmb.2010.09.007.

Teese MG, Campbell PM, Scott C, Gordon KHJ, Southon A, Hovan D, Robin C, Russell RJ & Oakeshott JG (2010) Gene identification and proteomic analysis of the esterases of the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology 40: (1)1-16 http://dx.doi.org/10.1016/j.ibmb.2009.12.002.

Farnsworth CA, Teese MG, Yuan G, Li Y, Scott C, Zhang X, Wu Y, Russell RJ & Oakeshott JG (2010) Esterase-based metabolic resistance to insecticides in heliothine and spodopteran pests. Journal of Pesticide Science 35: (3)275-289 http://dx.doi.org/10.1584/jpestics.R10-13.

Scott C, Pandey G, Hartley CJ, Jackson CJ, Cheesman MJ, Taylor MC, Pandey R, Khurana JL, Teese MG, Coppin CW, Weir KM, Jain RK, Lal R, Russell RJ & Oakeshott JG (2009) The enzymatic basis for pesticide bioremediation. Indian Journal of Microbiology 48: 65-79 http://dx.doi.org/10.1007%2Fs12088-008-0007-4.

Pompe T, Keller K, Mothes G, Nitschke M, Teese M, Zimmermann R & Werner C (2007) Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion. Biomaterials 28: (1)28-37 http://dx.doi.org/10.1016/j.biomaterials.2006.08.028.

 

 

Posters

Teese MG & Langosch D Are transmembrane helices really more conserved than soluble domains? FASEB Molecular Biophysics of Membranes Big Sky, Montana, USA. 29 June - 04 July 2014.

Löppenberg M, Teese MG, Jose J & Holl R Autodisplay of LpxC in Escherichia coli. DPhG-Jahrestagung Freiburg  09-11 Oct. 2013

Löppenberg M, Teese M, Jose J & Holl R Development of a LpxC enzyme assay for inhibitor testing. GDCh Fachgruppentagung "Frontiers in Medicinal Chemistry" Munich, Germany  17-20 Mar. 2013

Tubeleviciute A, Teese M & Jose J Discovery of a novel bacterial steroid dehydrogenase. 6th International Congress on Biocatalysis Hamburg  2-6 Sept. 2012

Schumacher SD, Teese MG, Hannemann F, Bernhardt R & Jose J Autodisplay of functional P450 monooxygenases. 6th International Congress on Biocatalysis Hamburg  2-6 Sept. 2012

Teese MG, Campbell PM, Scott C, Gordon KHJ, Robin C, Russell RJ & Oakeshott JG Putative identification of carboxylesterase isozymes from Helicoverpa armigera, the cotton bollworm. International Symposium on Insect Midgut Biology, Guangzhou, China  7-11 April 2008

Teese MG, Pompe T, Nitschke M, Zimmermann R & Werner C Low pressure plasma surface modification of polyhydroxyalkanoate films for modulating cellular response. 7th World Biomaterials Conference Sydney, Australia  17-21 May 2004

Werner C, Pompe T, Teese MG & Nitschke M Molecular surface engineering platforms to switch the characteristics of immobilised biopolymers. 7th World Biomaterials Congress Sydney, Australia  17-21 May 2004